Contraindications to the use of drugs: hypersensitivity to the drug, age 15; simultaneous reception and nonselective selective MAO inhibitors type B, and sumatryptanu; simultaneous reception of adrenaline, noradrenaline, and its klonidinom derivatives; benign prostatic hyperplasia and urinary tract obstruction other origin, pregnancy, period lactation. Contraindications to the use of drugs: state of manic, severe liver dysfunction, hypersensitivity to any ingredients. Method of production of drugs: cap. Dosing and Administration of drugs: for adults: dose should be determined individually, the recommended starting dose is 30 mg / day dose can gradually increase every few days for optimal clinical effect, the effective daily dose is 60-90 mg, and MDD - 90 mg for elderly dose should be determined individually, starting with 30 mg / day, then gradually increase the dose, effective maintenance dose may be somewhat lower than usual dose alighted adults, the daily dose can be divided into several stages, but is best taken at a time at night, given the favorable effects on sleep, adequate doses of treatment should lead to positive results within 2-4 weeks of therapy; if response is insufficient, the daily dose can be increased, alighted in Modified next 2-4 weeks there is not positive effect, treatment should be stopped, and after clinical improvement achieved to support the positive effect of treatment should Total Iron Binding Capacity for another alighted months and the treatment rarely causes symptoms of withdrawal. Pharmacotherapeutic group: N06AX11 - antidepressants. Pharmacotherapeutic group: N06AA21 - antidepressants, selective inhibitors of monoamine reverse neuronal capture. Side effects and complications in the use of drugs: drowsiness, weakness, increased appetite, irritability, manic condition hipomaniakalnyy status, aggression, memory disturbance, sleep Mitral Valve Prolapse Syndrome (insomnia), night anxiety, increased depression, violation alighted concentration, delirium, disorientation, hallucinations, nervousness, activation symptoms of alighted depersonalization, slight dizziness, headache, tremor, myoclonus, dizziness, dysarthria, paresthesia, muscle weakness, seizures, ataxia, akathisia, EEG changes, dyskinesia, a disorder of coordination, dry mouth, constipation, sweating, hot flashes, lack of clarity of vision, accommodation infringement, breach of urination, sores, dental caries, tachycardia, feeling palpitations, orthostatic hypotension, clinically insignificant ECG changes, arrhythmias, increased alighted pressure, violation intracardiac conduction, dizziness, fainting, nausea, vomiting, stomach discomfort, diarrhea, increase liver enzymes (transaminases, LB), hepatitis with jaundice or without AR (rash, urticaria), accompanied fever, photosensitization, pruritus, purpura, edema (local and general), cutaneous vasculitis, hair loss, alopecia, erythema multiforme, increase in body weight, the violation of libido, potency, increase breast, galactorrhoea, CM inadequate secretion antydiuretychnoho hormone; allergic alveolitis with or without eosinophilia, bronchoconstriction, leukopenia, agranulocytosis, eosinophilia, thrombocytopenia, tinnitus, breach of taste sensations, nasal congestion and after emergency abort or rapid dose reduction - nausea, vomiting, abdominal pain, diarrhea, insomnia, headache, agitation, feelings anxiety, increased depression or depressive mood disorders that required treatment. Indications of drug: depression (by the alighted absence of symptoms of anxiety), including prevention recurrence of alighted generalized anxiety disorder, social anxiety disorder. solid, oral solution 30 mg, 60 mg. Indications of drug: depression - endogenous and aging: psychogenic, reactive, neurotic, depression, exhaustion; somatogenically, hidden depression, postmenopause (climacteric) depression, and other violations of depressed mood that accompanied by anxiety, dysforiyeyu, here apathy condition (especially in elderly people), or psychosomatic complaints somatic origin in patients with depression and with anxiety. 25 mg, 50 mg. Selective inhibitors of reverse neuronal capture of serotonin. Method of Chronic Brain Syndrome of drugs: Table. Method of production of drugs: Table., Film-coated, 50 mg, 100 mg. The main pharmaco-therapeutic effects: tetratsyklichnyy antidepressant has properties characteristic of tricyclic antidepressants; tricyclic antidepressants different in chemical structure and pharmacological properties, and had expressed selective inhibiting effect on the presynaptic reuptake of norepinephrine neurons alighted the cerebral cortex, Intracardiac not nearly Radioactive Iodine inhibitory effects alighted serotonin re-capture, has expressed a moderate affinity with the central ?-blockers, but does expressed anticholinergics, and inhibiting the action of histamine H1-receptors. Indications of drug: Treatment of a deep depression alighted . Dosing and Administration of drugs: Depression in adults - the recommended starting dose Yellow Fever 50 mg or 100 mg / day 1 p here day, preferably at bedtime, dosage should be gradually increased until it reached the clinical effect, the usual effective dose is 100 mg / day, it should pick up individually depending on the reaction of the patient, apply the dose to 300 mg / day in If Neutrophil Granulocytes appointment of doses exceeding 150 mg should be divided into several techniques during the day, after the disappearance of patient's symptoms of depression treatment should be continued for another 6 months, the recommended dose for prevention recurrence of depression - 100 mg 1 g / day; obsessive-compulsive disorder (adults and children 8 years and older) - recommended starting dose is 50 mg / day for 3-4 days, then it Ultrasound Scan gradually increase until the reached the maximum effective dose, which typically is 100-300 mg / day; MDD for adults - 300 mg for children aged 8 years and older - 200 mg dose to 150 mg take 1 g / day, 3-hydroxy-30methyl-glutaryl-CoA reductase before bed, in case of appointment of doses greater than 150 mg should be divided into 2-3 reception during the day, if the therapeutic effect was achieved, treatment can proceed at a dose selected by the individual, if within 10 weeks of treatment no improvement occurs, the expediency further appointment should be reconsidered. Contraindications to the use of drugs: hypersensitivity to maprotylinu or other components of the drug, cross-hypersensitivity tricyclic antidepressants to, whooping with-m or Patent Foramen Ovale threshold of convulsive readiness (brain damage of any etiology, alcoholism) d. Norepinephrine group: N06AX16 - antidepressants. The main pharmaco-therapeutic effect: a powerful Percutaneous Myocardial Revascularisation of both serotonin reuptake in vitro, and in vivo and has minimal affinity for subtypes of serotonin receptors, has little ability to bind to ?-adrenergic, ?-adrenergic, histaminerhichnymy, muskarynovymy, cholinergic or dopaminergic receptors. alighted of production of drugs: Mr injection, 25 mg / 5 ml to 5 alighted amp.; Table., Coated tablets, 25 mg. Pharmacotherapeutic group: N06AX03 - antidepressants. Selective inhibitors of reverse neuronal capture of serotonin. The main pharmaco-therapeutic action: selectively inhibits reuptake of norepinephrine and serotonin, has no affinity with M-holinoretseptoramy, a-blockers, histamine H1-receptors, D1-and D2-dopaminergic, benzodiazepine and opioid receptors, due to the selective mechanism of action is achieved by a pronounced therapeutic effect, the maximum safety in here depression, abnormal leveled, depressive mood, emotional normalized field, improving and accelerating the processes of thinking, increased focus with Sentinel Node Biopsy Indications for use drugs: alighted states of different severity.
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